You can buy 5-Amino-1MQ from online research-chemical suppliers, and that's the only route there is, because no pharmacy stocks it and no prescription exists to write. Here's the thing nobody mentions while you shop: it isn't a peptide. It has zero amino acids, no peptide bonds, and weighs just 159 g/mol.
5-Amino-1MQ
Referenced in this guideThe 5-Amino-1MQ referenced throughout this article, supplied as a research compound with a certificate of analysis matched to the lot you receive — the check this site argues you should hold any supplier to.
5-Amino-1MQ is a small-molecule NNMT blocker, not a peptide, and it sells legally in the US as a research reference compound. Expect $50–$150 per 50 mg vial, roughly 10x cheaper per milligram than peptides. A good lab report shows HPLC purity above 98%, mass-spec at 159.1 m/z, and CAS 42464-96-0, and every published efficacy study is in rodents.
Quick answer: Buy a 50 mg vial labeled with CAS 42464-96-0 and molecular weight 159.21 g/mol. Pay $50–$150. Get a lab report from an ISO 17025 lab, an internationally recognized testing standard, that tests small molecules rather than peptides. Set your evidence expectations to mouse-only.
Where can you buy 5-Amino-1MQ?
5-Amino-1MQ has exactly one open channel: online research-chemical suppliers, sold under research-use-only labeling with no prescription. No pharmacy stocks it. No compounding pharmacy can prepare it. No registered human trial is recruiting. We'd rather say that plainly than pad the list out.
- Research-chemical suppliers, online. The only route. Sold under research-use-only labeling, no prescription, shipped by mail. It sits in the same catalogs as BPC-157 and tirzepatide because the same warehouses ship all three.
- Compounding pharmacy: not applicable. Compounding needs an approved active ingredient. 5-Amino-1MQ has none. It's a small molecule, so it also sits outside the FDA's 2023 peptide-compounding categories entirely.
- Retail pharmacy: nothing to dispense. No FDA approval, no indication, no prescription for a pharmacist to fill.
- Clinical trial: none we can point you to. Ridgeline Therapeutics has signaled interest in clinical development. No registered human trial has read out.
Which suppliers to shortlist
Six vendors, ordered the way our supplier comparison orders them — on what each one will show you rather than what it claims — with every column pulled from the vendor's own storefront on 13 August 2026; there is no verified 5-Amino-1MQ price anywhere in that set, so pricing is benchmarked on BPC-157 across the same vendors and no price column appears here.
| Vendor | COA | Lab named | Ships free at |
|---|---|---|---|
| Peptriva Premium brand | Third-party, published | Freedom Diagnostics — on the product page | $200 |
| Sports Technology Labs | Third-party, published | MZ Biolabs + Colmaric — on the site and the document | $149 |
| Swiss Chems | Third-party, published | Janoshik — on the site (FAQ) | $100 |
| Core Peptides | Third-party, published (A2LA #6377.01.01) | Vanguard Laboratory — document only | $200 |
| PS Peptides | Third-party, published | North American Diagnostics — document only | $200 |
| Limitless Biotech† | Third-party, hosted on Google Drive | Janoshik — on the document, not the site | Not offered |
† Limitless Biotech gates every price behind an account, so nothing it sells can be compared until you have registered. Stock varies by compound, so confirm a vendor actually lists 5-Amino-1MQ before you compare — what these columns describe is disclosure practice, and that is the part that travels across every compound a vendor sells. Disclosure: this site earns a commission on purchases made through its links, and Peptriva is one of the vendors it links to. Every column above is a document you can open or a page you can load yourself.
The identity check to run against whichever vendor you pick is CAS 42464-96-0 on the certificate's identity line, confirmed by a mass-spec ion at m/z 159.1 rather than by a purity percentage on its own.
What is 5-Amino-1MQ, actually?
5-Amino-1MQ is a small molecule, not a peptide, and it blocks an enzyme called NNMT, short for nicotinamide N-methyltransferase. NNMT chews through two valuable cellular resources at once. One is SAM, a methyl-donor molecule. The other is nicotinamide, the precursor cells use to build NAD+.
When NNMT runs hot in fat tissue, aging muscle or tumors, it drains both supplies. Blocking it restores them. That's the science, the biology is interesting, and the compound is real. It just isn't a peptide.
A peptide is a chain of amino acids joined by amide bonds. The smallest ones we cover, selank and semax, have at least seven amino acids and weigh over 700 g/mol. 5-Amino-1MQ has zero amino acids and weighs 159 g/mol. It's a flat aromatic ring with two nitrogens.
It ships in the “research peptide” category because the same warehouses ship both. That's a logistics fact, not a chemistry fact.
How do you verify 5-Amino-1MQ before you buy?
Four checks settle 5-Amino-1MQ specifically. Read the lab report for small-molecule data rather than a sequence. Set evidence expectations to rodent-only. Treat oral dosing as a rodent finding. Price it as a small molecule. Our eight general criteria apply on top.
1. The lab report must list small-molecule data, not a peptide sequence
A credible Certificate of Analysis for 5-Amino-1MQ shows three things on the identity line:
- Molecular formula: C10H11N2 for the active cation, or C10H11N2I for the iodide salt as sold.
- Molecular weight: 159.21 g/mol for the cation.
- IUPAC name: includes “quinolin-1-ium.”
If the report lists an amino-acid sequence, the vendor is on autopilot. You can cross-check the CAS number against PubChem in 30 seconds. 42464-96-0 is the only correct entry.
2. Set evidence expectations to rodent-only
The entire efficacy literature for 5-Amino-1MQ comes down to two preclinical studies:
- A 2022 mouse study showing fat-mass reductions when 5-Amino-1MQ was paired with a diet switch. Dimet-Wiley et al., 2022.
- A 2024 mouse study showing tumor shrinkage in bladder cancer models when combined with an immunotherapy antibody. Yang et al., 2024.
A 2021 cervical-cancer paper by Akar and colleagues used a closely related compound, not 5-Amino-1MQ itself.
That's the whole literature. Zero human trials have been published as of May 2026. Anyone extrapolating from a mouse fat-pad to a human body-weight outcome is crossing the largest inferential gap in pharmacology with no safety net.
3. Oral bioavailability is a real differentiator
5-Amino-1MQ is small and stable enough to survive a stomach. The Dimet-Wiley team dosed mice by oral gavage and saw biological activity.
Most peptides can't do that. BPC-157, tirzepatide and retatrutide all need injection, because gut enzymes destroy peptide bonds in minutes. It's a legitimate point in 5-Amino-1MQ's favor. But it's only validated in mice, and human oral pharmacokinetics aren't characterized yet.
4. Pricing follows different math
Peptides are made by solid-phase peptide synthesis, which is expensive per milligram. Small molecules like 5-Amino-1MQ are made by classical organic chemistry, which isn't. The cost gap is roughly 10x:
- 5-Amino-1MQ: $1–$3 per mg, about $60 for a 50 mg vial.
- BPC-157: $5–$10 per mg.
- Tirzepatide: $15–$30 per mg.
Watch the vial size when you compare prices. A $60 vial holding only 5 mg is peptide pricing applied to a non-peptide. The standard size is 50 mg.
Where this falls short: The all-rodent evidence base is the single biggest limitation. There's no published human safety profile, no characterized human dosing, and no controlled efficacy data outside mice.
The compound's commercial sponsor, Ridgeline Therapeutics, has signaled interest in clinical development. Until a registered trial reads out, every claim about NNMT inhibition and body weight is extrapolation. Buy it for what it is: a research tool, not a therapeutic.
What does 5-Amino-1MQ cost in 2026?
5-Amino-1MQ runs $50–$80 for the standard 50 mg vial, $80–$120 for 100 mg and $130–$200 for 250 mg. That works out at $1–$3 per milligram. It's cheap because the synthesis is cheap. Here's what we see across third-party tested retail.
- 50 mg vial: $50–$80, or $1.00–$1.60 per mg. The standard retail size.
- 100 mg vial: $80–$120, or $0.80–$1.20 per mg. Good for sustained rodent protocols.
- 250 mg vial: $130–$200, or $0.50–$0.80 per mg. Lab-scale work.
- 500 mg or 1 g vial: available from specialty suppliers with further per-mg discounts.
Anything below $30 per 50 mg deserves a second look. At that floor, the common substitutions are the demethylated precursor 5-aminoquinoline, CAS 611-34-7, or the unaminated analog 5-methylquinolinium. They look similar on a partial chromatogram. They aren't the compound used in the Watowich studies.
Is 5-Amino-1MQ legal to buy?
Yes. 5-Amino-1MQ sells legally in the US as a research reference compound labeled for laboratory use only. It isn't a controlled substance and isn't scheduled by the DEA. Because it's a small molecule, it sits outside the FDA's 2023 peptide-compounding rules entirely.
The catch: selling it with obesity-indication claims for human use triggers FDA enforcement whatever the chemistry says. The research-use-only framework under 21 CFR § 809.10(b)(9) allows sale as research material. It doesn't allow a vendor to call it an obesity drug.
WADA hasn't added 5-Amino-1MQ to the Prohibited List as of 2026. If your study participants fall under WADA jurisdiction, check the current WADA Prohibited List. Metabolic-modulating compounds are an active anti-doping watch area.
What are the red flags when buying 5-Amino-1MQ?
Six 5-Amino-1MQ warning signs we’d walk away from:
- Sold as a “peptide.” The vendor either doesn’t know what the molecule is or is comfortable misrepresenting it. Either way, it’s a quality-control red flag for the rest of their catalog.
- Priced like a peptide. A 5 mg vial at $60–$80 is peptide pricing applied to a small molecule. The standard size is 50 mg at that price.
- Lab report from a peptide-focused lab. Peptide HPLC methods don’t cleanly transfer to small molecules. Look for a lab that tests small-molecule pharmaceutical intermediates.
- “GLP-1 alternative” marketing. Anyone framing 5-Amino-1MQ as a substitute for Ozempic is making clinical claims about a compound with zero human trials. That’s the exact pattern that draws FDA letters.
- Missing CAS number 42464-96-0. The CAS is the molecule’s ID number. If it’s missing, or replaced with the precursor's 611-34-7, that’s the wrong compound.
- Pre-reconstituted liquid. 5-Amino-1MQ ships stable as a freeze-dried iodide salt at −20°C. Liquid solutions sold at room temperature degrade, including by exposure to light.
5-Amino-1MQ
5-Amino-1-methylquinolinium iodide, CAS 42464-96-0. A small-molecule NNMT inhibitor with the reference identity used across the published Watowich-lab preclinical literature. COA tested by small-molecule-appropriate HPLC and mass-spec methods ships with every order.
Frequently asked questions
Is 5-Amino-1MQ legal to buy in the USA?
Yes, as a research reference compound. It isn't a controlled substance, isn't FDA-approved for any indication, and isn't scheduled by the DEA. Because it's a small molecule, it sits outside the FDA's 2023 peptide-compounding rules. Vendors may not market it with human-use claims.
Is 5-Amino-1MQ actually a peptide?
No. It has no amino acids and no peptide bonds. It's a small-molecule quinolinium, a flat aromatic ring with two nitrogens, weighing 159.21 g/mol. That's about one-tenth the size of the smallest real peptide. The “peptide” framing is marketing language, not chemistry.
How much should third-party tested 5-Amino-1MQ cost?
Pay $50–$80 for a 50 mg vial, $80–$120 for 100 mg, or $130–$200 for 250 mg. That's roughly $1–$3 per mg. Compare it with $5–$20 per mg for most peptides. The synthesis method is what drives the gap. Below $30 per 50 mg deserves a question.
What does the human evidence actually show?
Nothing. There are zero PubMed-indexed human trials for 5-Amino-1MQ as of May 2026. Every efficacy claim rests on rodent or cell-culture data. Ridgeline Therapeutics has signaled interest in human development, but no clinical readouts exist yet.
Is 5-Amino-1MQ a real alternative to Ozempic or tirzepatide?
No, and the comparison is misleading. Tirzepatide and semaglutide are FDA-approved, with Phase III trials in tens of thousands of people and documented mean body-weight reduction of 15–22% from baseline. 5-Amino-1MQ has only rodent data. It may be useful in preclinical NNMT work. It has no published human efficacy or safety data.
How does NNMT inhibition affect metabolic activity in preclinical models?
NNMT consumes two cellular resources at once: SAM, a methyl donor, and nicotinamide, the NAD+ precursor. In obese adipose tissue in rodent models, elevated NNMT activity has been reported to deplete both.
Preclinical studies have investigated whether inhibiting NNMT increases cellular energy expenditure, and Dimet-Wiley and colleagues reported such effects in DIO mice in 2022. Our mechanism article walks through the biochemistry, and the metabolic research article covers the rodent findings in detail.
What to know now
- Online research-chemical suppliers are the only route. There is no pharmacy or compounding channel for it.
- CAS 42464-96-0, MW 159.21 g/mol, formula C10H11N2. The numbers a credible lab report should show.
- $50–$150 per 50 mg vial. Small-molecule synthesis is roughly 10x cheaper per mg than peptide synthesis.
- Not a peptide. Zero amino acids, sold in the peptide category by warehouse convention only.
- Mouse-only evidence. DIO obesity model plus bladder cancer xenograft. No human trials published.
- Orally bioavailable in rodents. A real differentiator from injectable peptides, but human pharmacokinetics aren’t characterized.
- Not a GLP-1 alternative. Marketing that compares it to Ozempic ignores the evidence gap.
What we’re watching
The development we're tracking is whether Ridgeline Therapeutics or another sponsor moves an NNMT inhibitor into a registered human trial. The 2024 bladder-cancer paper in Journal for ImmunoTherapy of Cancer is the kind of preclinical signal that often precedes serious development.
Until a Phase I readout appears, the human-translation question stays open. We're also watching whether WADA adds metabolic NNMT inhibitors to its Prohibited List as a class.
References
- Dimet-Wiley, A., Wu, Q., Wiley, J. T., Eswar, A., Neelakantan, H., Savidge, T. C., & Watowich, S. J. (2022). Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice. Scientific Reports, 12(1), 484. https://doi.org/10.1038/s41598-021-03670-5
- Yang, M., Wang, B., Hou, W., Yu, H., Zhou, B., Zhong, W., Liu, Z., Li, J., Zhang, H., Yang, G., & Wang, X. (2024). NAD+ metabolism enzyme NNMT in cancer-associated fibroblasts drives tumor progression and resistance to immunotherapy by modulating macrophages in urothelial bladder cancer. Journal for ImmunoTherapy of Cancer, 12(7), e009281. https://doi.org/10.1136/jitc-2024-009281
- Akar, S., Duran, T., Azzawri, A. A., Koçak, N., Çelik, Ç., & Yıldırım, H. İ. (2021). Small molecule inhibitor of nicotinamide N-methyltransferase shows anti-proliferative activity in HeLa cells. Journal of Obstetrics and Gynaecology, 41(8), 1240–1245. https://doi.org/10.1080/01443615.2020.1854696
- U.S. Food and Drug Administration. (2023). Section 503A of the Federal Food, Drug, and Cosmetic Act. https://www.fda.gov/drugs/human-drug-compounding/section-503a-federal-food-drug-and-cosmetic-act
- U.S. Code of Federal Regulations. (2024). 21 CFR § 809.10(b)(9) — Labeling for in vitro diagnostic products: Research use only. https://www.ecfr.gov/current/title-21/chapter-I/subchapter-H/part-809/section-809.10
- World Anti-Doping Agency. (2026). The 2026 Prohibited List. https://www.wada-ama.org/en/prohibited-list
- International Organization for Standardization. (2017). ISO/IEC 17025:2017 — General requirements for the competence of testing and calibration laboratories. https://www.iso.org/standard/66912.html
